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Вакцина против ВИЧ усиливает эффект АРВ терапии

Вакцина против ВИЧ усиливает эффект АРВ терапии
HIV vaccine

Вакцина против ВИЧ усиливает эффект антиретровирусных препаратов

Вакцина, содержащая белок, который играет решающую роль в воспроизводстве ВИЧ, повышает общую эффективность антиретровирусных препаратов (АРВП). Исследователи, которые опубликовали свои выводы в журнале «Ретровирусология», в фазе II клинических испытаний разработали вакцину, которая включает в себя небольшое количество белка ТАТ, фермента, который поддерживает жизнедеятельность вируса, сообщает сайт aidsmeds.com.

Исследователи вводили вакцину, содержащую 7,5 или 30 микрограммов ТАТ 168 ВИЧ-положительным участникам исследования. Участники, все из которых принимали антиретровирусные препараты, делали прививку один раз в месяц в течение трех или пяти месяцев. Исследователи наблюдали за участниками в течение трех лет.
Благодаря прививке иммунная система участников исследования начала вырабатывать антитела к белку ТАТ. У участников повысилось количество клеток CD4, а также T, B и других иммунных клеток. Действие вакцины сохранялось в течение всего времени исследования. Чем больше была доза вакцины, которую кололи в течение трех месяцев, тем сильнее была ее эффективность.

Вакцина также вызвала сокращение провирусной ДНК ВИЧ, что свидетельствует об уменьшении вирусного резервуара. Чтобы установить этот факт, исследователи сравнили участников исследования с 79 участниками другого наблюдательного исследования, которые также принимали АРВП. По сути, участники этого исследования сыграли роль контрольной группы.

Вакцина против ВИЧ усиливает эффект АРВ терапии

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