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Ученые: Переход от ВИЧ к СПИД ускоряют гены

Ученые: Переход от ВИЧ к СПИД ускоряют гены

Исследование ученых из ЮАР и США продемонстрировало важную связь между генами и скоростью развития СПИД.

Ученые прежде не понимали, почему у ВИЧ-положительных СПИД проявляется в разное время, но подозревали, что это может быть связано с генами. Последние исследования показали, как специфические гены приводят к более быстрому прогрессированию болезней, связанных со СПИДом, у ВИЧ-инфицированных, которые не получают высокоактивную антиретровирусной терапии.

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Ученые увидели как ВИЧ проникает в клетку в реальном времени

Исследователи обнаружили специфическую разновидность человеческого лейкоцитарного антигена (HLA), который помогает инфицированным клеткам проникать сквозь первую линию обороны организма. Наблюдения за 9 763 людьми, имеющими ВИЧ и проживающими в Южной Африке и США, показали, что наличие специфического типа HLA ускоряет процесс перехода ВИЧ-инфекции в стадию СПИДа. Вирусная нагрузка у обладателей этого типа гена была более высокой, а их иммунные клетки CD4 разрушались более быстро ещё перед тем, как люди успевали начать антиретровирусную терапию.

По оценкам ученых, у двух миллионов ВИЧ-инфицированных в ЮАР из общего их числа в 7 млн имеется специфическая разновидность гена HLA. Автор исследования профессор Салим Абдулкарим подчеркнул, что и раньше замечал: если 10 человек стали одновременно ВИЧ-инфицированными, то каждого из них СПИД появится в разное время. Ученый не знал, с чем это связано, до самого последнего времени.

Ученые: Переход от ВИЧ к СПИД ускоряют гены

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