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Одна таблетка в день для лечения ВИЧ

Одна таблетка в день для лечения ВИЧ

FDA (Управление по контролю за пищевыми продуктами и лекарственными средствами США -Американский Роспотребнадзор) несколько дней назад одобрило совершенно новый препарат, содержащий в себе 4 антивирусных лекарственных средства.

Стрибилд - находка Gilead Sciences (фарм. компания), содержит элвитегравир, кобицистат, эмтрицитабин и тенофовир. Область применения - лечение ВИЧ-инфекции среди пациентов, никогда не принимавших антиретровирусные препараты, то есть тех, кто только начинает лечение. Принимать Стрибилд нужно всего 1 раз в день, что чрезвычайно удобно для людей с ВИЧ.

Лекарственные средства кобицистат и элвитегравир совсем недавно появились, действие элвитегравира заключается в блокировании фермента, необходимого для вирусной репликации, а функция кобицистата - ингибирование работы фермента, метаболизирующего антиретровирусные препараты, таким образом, он продлевает действие элвитегравира.
Препараты подобные Стрибилду помогут упростить прием антиретровирусной терапии пациентами и повысят приверженность. К тому же по результатам исследований вирусологической удачи удавалось добиться через 48 недель после начала терапии у 88−90% пациентов.

Однако у препарата есть серьезные побочные эффекты, к которым относятся: лактатацидоз, нарушение функции печени, диарея, слабость, нарушение работы почек, снижение плотности костной ткани, перераспределение жировой ткани.
FDA заявляет, что дальнейшие исследования препарата будут проводиться для детального изучения влияния на организм детей и женщин, формирования резистентности и возможных взаимодействий с другими лекарственными средствами.

Источник: nih.gov

Одна таблетка в день для лечения ВИЧ

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112 Comments

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